8p7l

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Current revision (08:19, 20 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8p7l is ON HOLD
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==Cryo-EM structure of CDK7 subunit of CAK in complex with inhibitor LDC4297==
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<StructureSection load='8p7l' size='340' side='right'caption='[[8p7l]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8p7l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P7L FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WD9:2-[(3S)-piperidin-3-yl]oxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine'>WD9</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p7l OCA], [https://pdbe.org/8p7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p7l RCSB], [https://www.ebi.ac.uk/pdbsum/8p7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p7l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAT1_HUMAN MAT1_HUMAN] Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.<ref>PMID:10024882</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ali S]]
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[[Category: Bahl AK]]
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[[Category: Cushing VI]]
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[[Category: Feng J]]
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[[Category: Greber BJ]]
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[[Category: Jurgaityte K]]
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[[Category: Koh AF]]
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[[Category: Kotecha A]]

Current revision

Cryo-EM structure of CDK7 subunit of CAK in complex with inhibitor LDC4297

PDB ID 8p7l

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OCA

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