8q4i

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Current revision (08:19, 20 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8q4i is ON HOLD until Paper Publication
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==The crystal structure of human chloride intracellular channel protein 5 delta 57-68==
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<StructureSection load='8q4i' size='340' side='right'caption='[[8q4i]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8q4i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Q4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Q4I FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8q4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8q4i OCA], [https://pdbe.org/8q4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8q4i RCSB], [https://www.ebi.ac.uk/pdbsum/8q4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8q4i ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CLIC5_HUMAN CLIC5_HUMAN] Autosomal recessive non-syndromic sensorineural deafness type DFNB. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/CLIC5_HUMAN CLIC5_HUMAN] Required for normal hearing (PubMed:24781754). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed:15184393, PubMed:18028448, PubMed:20335315). Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens (By similarity).[UniProtKB:Q8BXK9]<ref>PMID:15184393</ref> <ref>PMID:18028448</ref> <ref>PMID:20335315</ref> <ref>PMID:24781754</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Giladi M]]
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[[Category: Haitin Y]]
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[[Category: Manori B]]

Current revision

The crystal structure of human chloride intracellular channel protein 5 delta 57-68

PDB ID 8q4i

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