3hvh
From Proteopedia
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<StructureSection load='3hvh' size='340' side='right'caption='[[3hvh]], [[Resolution|resolution]] 1.30Å' scene=''> | <StructureSection load='3hvh' size='340' side='right'caption='[[3hvh]], [[Resolution|resolution]] 1.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3hvh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3hvh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HVH FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=542:N-[(E)-3-[(2R,3S,4R,5R)-3,4-DIHYDROXY-5-(6-METHYLAMINOPURIN-9-YL)OXOLAN-2-YL]PROP-2-ENYL]-5-(4-FLUOROPHENYL)-2,3-DIHYDROXY-BENZAMIDE'>542</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=542:N-[(E)-3-[(2R,3S,4R,5R)-3,4-DIHYDROXY-5-(6-METHYLAMINOPURIN-9-YL)OXOLAN-2-YL]PROP-2-ENYL]-5-(4-FLUOROPHENYL)-2,3-DIHYDROXY-BENZAMIDE'>542</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hvh OCA], [https://pdbe.org/3hvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hvh RCSB], [https://www.ebi.ac.uk/pdbsum/3hvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hvh ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hvh OCA], [https://pdbe.org/3hvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hvh RCSB], [https://www.ebi.ac.uk/pdbsum/3hvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hvh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Buffalo rat]] | ||
| - | [[Category: Catechol O-methyltransferase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Benz | + | [[Category: Rattus norvegicus]] |
| - | [[Category: Ehler | + | [[Category: Benz J]] |
| - | [[Category: Rudolph | + | [[Category: Ehler A]] |
| - | [[Category: Schlatter | + | [[Category: Rudolph MG]] |
| - | [[Category: Stihle | + | [[Category: Schlatter D]] |
| - | + | [[Category: Stihle M]] | |
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Current revision
Rat catechol O-methyltransferase in complex with a catechol-type, N6-methyladenine-containing bisubstrate inhibitor
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