3hz5
From Proteopedia
(Difference between revisions)
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<StructureSection load='3hz5' size='340' side='right'caption='[[3hz5]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='3hz5' size='340' side='right'caption='[[3hz5]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3hz5]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3hz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HZ5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Z64:N-[4-(5-FURAN-2-YL-3-METHYL-1H-PYRAZOL-4-YL)BUTYL]-N-METHYL-7H-PURIN-6-AMINE'>Z64</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Z64:N-[4-(5-FURAN-2-YL-3-METHYL-1H-PYRAZOL-4-YL)BUTYL]-N-METHYL-7H-PURIN-6-AMINE'>Z64</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hz5 OCA], [https://pdbe.org/3hz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hz5 RCSB], [https://www.ebi.ac.uk/pdbsum/3hz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hz5 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Barker | + | [[Category: Barker J]] |
| - | [[Category: Cheng | + | [[Category: Cheng RKY]] |
| - | [[Category: Felicetti | + | [[Category: Felicetti B]] |
| - | [[Category: Mather | + | [[Category: Mather O]] |
| - | [[Category: Palan | + | [[Category: Palan S]] |
| - | [[Category: Whittaker | + | [[Category: Whittaker M]] |
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Current revision
Crystal structure of Hsp90 with fragment Z064
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Categories: Homo sapiens | Large Structures | Barker J | Cheng RKY | Felicetti B | Mather O | Palan S | Whittaker M
