3ird

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Current revision (08:28, 20 March 2024) (edit) (undo)
 
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<StructureSection load='3ird' size='340' side='right'caption='[[3ird]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
<StructureSection load='3ird' size='340' side='right'caption='[[3ird]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ird]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clobh Clobh]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3bi8 3bi8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IRD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ird]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum_A_str._Hall Clostridium botulinum A str. Hall]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3bi8 3bi8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IRD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3bi8|3bi8]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dapA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=441771 CLOBH])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ird FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ird OCA], [https://pdbe.org/3ird PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ird RCSB], [https://www.ebi.ac.uk/pdbsum/3ird PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ird ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ird FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ird OCA], [https://pdbe.org/3ird PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ird RCSB], [https://www.ebi.ac.uk/pdbsum/3ird PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ird ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/A5I6N2_CLOBH A5I6N2_CLOBH]] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).[HAMAP-Rule:MF_00418][SAAS:SAAS00021616]
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[https://www.uniprot.org/uniprot/A5I6N2_CLOBH A5I6N2_CLOBH] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).[HAMAP-Rule:MF_00418][SAAS:SAAS00021616]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]
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[[Category: Clostridium botulinum A str. Hall]]
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[[Category: Clobh]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Atkinson, S]]
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[[Category: Atkinson S]]
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[[Category: Dobson, R C.J]]
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[[Category: Dobson RCJ]]
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[[Category: Perugini, M A]]
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[[Category: Perugini MA]]
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[[Category: Amino-acid biosynthesis]]
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[[Category: Clostridium botulinum]]
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[[Category: Diaminopimelate biosynthesis]]
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[[Category: Dihydrodipicolinate synthase]]
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[[Category: Lyase]]
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[[Category: Lysine biosynthesis]]
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[[Category: Schiff base]]
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Current revision

Structure of dihydrodipicolinate synthase from Clostridium botulinum

PDB ID 3ird

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