3rby

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Current revision (08:35, 20 March 2024) (edit) (undo)
 
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<StructureSection load='3rby' size='340' side='right'caption='[[3rby]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3rby' size='340' side='right'caption='[[3rby]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3rby]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RBY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3rby]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RBY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.301&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YLR301W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rby OCA], [https://pdbe.org/3rby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rby RCSB], [https://www.ebi.ac.uk/pdbsum/3rby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rby ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rby OCA], [https://pdbe.org/3rby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rby RCSB], [https://www.ebi.ac.uk/pdbsum/3rby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rby ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/HRI1_YEAST HRI1_YEAST]] Unknown. Non essential.
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[https://www.uniprot.org/uniprot/HRI1_YEAST HRI1_YEAST] Unknown. Non essential.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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When the Z-type variant of human alpha(1)-antitrypsin was overexpressed in Saccharomyces cerevisiae, proteomics analysis identified YLR301w as one of the up-regulated proteins. YLR301w is a 27.5 kDa protein with no sequence homology to any known protein and has been reported to interact with Sec72 and Hrr25. The crystal structure of S. cerevisiae YLR301w has been determined at 2.3 A resolution, revealing a novel beta-structure. It consists of an N-terminal ten-stranded beta-barrel with two short alpha-helices connected by a 23-residue linker to a seven-stranded half-barrel with two short helices at the C-terminus. The N-terminal barrel has a highly conserved hydrophobic channel that can bind hydrophobic molecules such as PEG. It forms a homodimer both in the crystal and in solution. YLR301w binds Sec72 with a K(d) of 6.2 microM, but the biological significance of this binding requires further investigation.
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Novel beta-structure of YLR301w from Saccharomyces cerevisiae.,Kim KH, Ahn HJ, Lee WK, Lee C, Yu MH, Kim EE Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):531-40. Epub 2012 Apr 17. PMID:22525751<ref>PMID:22525751</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3rby" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 18824]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kim, E E]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Kim, K H]]
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[[Category: Kim EE]]
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[[Category: Beta-barrel]]
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[[Category: Kim K-H]]
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[[Category: Uncharacterized]]
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[[Category: Unknown function]]
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Current revision

Crystal structure of uncharacterized protein YLR301w from Saccharomycces cerevisiae

PDB ID 3rby

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