3stk

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Current revision (08:37, 20 March 2024) (edit) (undo)
 
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<StructureSection load='3stk' size='340' side='right'caption='[[3stk]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='3stk' size='340' side='right'caption='[[3stk]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3stk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3STK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3STK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3stk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3STK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3STK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3stm|3stm]], [[3stn|3stn]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3stk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3stk OCA], [https://pdbe.org/3stk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3stk RCSB], [https://www.ebi.ac.uk/pdbsum/3stk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3stk ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3stk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3stk OCA], [https://pdbe.org/3stk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3stk RCSB], [https://www.ebi.ac.uk/pdbsum/3stk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3stk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN]] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
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[https://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We crystallized human liver fatty acid binding protein (LFABP) in apo, holo and intermediate states of palmitic acid engagement. Structural snapshots of fatty acid recognition, entry and docking within LFABP support a heads in mechanism for ligand entry. Apo-LFABP undergoes structural remodeling where first palmitate ingress creates atomic environment for placement of second palmitate. These new mechanistic insights will facilitate development of pharmacological agents against LFABP.
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Fatty acid induced remodeling within the Human liver fatty acid binding protein.,Sharma A, Sharma A J Biol Chem. 2011 Jul 8. PMID:21757748<ref>PMID:21757748</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3stk" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]]
*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Sharma, A]]
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[[Category: Sharma A]]
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[[Category: Fatty acid binding]]
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[[Category: Lfabp]]
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[[Category: Lipid binding protein]]
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[[Category: Palmitic acid]]
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Current revision

Crystal Structure of human LFABP complex with two molecules of palmitic acid (holo-LFABP)

PDB ID 3stk

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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