3tcn

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Current revision (08:37, 20 March 2024) (edit) (undo)
 
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<StructureSection load='3tcn' size='340' side='right'caption='[[3tcn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3tcn' size='340' side='right'caption='[[3tcn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3tcn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TCN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3tcn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TCN FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3tck|3tck]], [[2z2i|2z2i]], [[2z2j|2z2j]], [[2z2k|2z2k]], [[2pth|2pth]], [[2jrc|2jrc]], [[3p2j|3p2j]], [[3td2|3td2]], [[3td6|3td6]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT1042, MTCY10G2.35, pth, Rv1014c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tcn OCA], [https://pdbe.org/3tcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tcn RCSB], [https://www.ebi.ac.uk/pdbsum/3tcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tcn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tcn OCA], [https://pdbe.org/3tcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tcn RCSB], [https://www.ebi.ac.uk/pdbsum/3tcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tcn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PTH_MYCTU PTH_MYCTU]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).
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[https://www.uniprot.org/uniprot/PTH_MYCTU PTH_MYCTU] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The X-ray structures of new crystal forms of peptidyl-tRNA hydrolase from M. tuberculosis reported here and the results of previous X-ray studies of the enzyme from different sources provide a picture of the functionally relevant plasticity of the protein molecule. The new X-ray results confirm the connection deduced previously between the closure of the lid at the peptide-binding site and the opening of the gate that separates the peptide-binding and tRNA-binding sites. The plasticity of the molecule indicated by X-ray structures is in general agreement with that deduced from the available solution NMR results. The correlation between the lid and the gate movements is not, however, observed in the NMR structure.
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Structures of new crystal forms of Mycobacterium tuberculosis peptidyl-tRNA hydrolase and functionally important plasticity of the molecule.,Selvaraj M, Ahmad R, Varshney U, Vijayan M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Feb 1;68(Pt, 2):124-8. Epub 2012 Jan 21. PMID:22297982<ref>PMID:22297982</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3tcn" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Peptidyl-tRNA hydrolase|Peptidyl-tRNA hydrolase]]
*[[Peptidyl-tRNA hydrolase|Peptidyl-tRNA hydrolase]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aminoacyl-tRNA hydrolase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Myctu]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Ahmad, R]]
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[[Category: Ahmad R]]
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[[Category: Selvaraj, M]]
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[[Category: Selvaraj M]]
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[[Category: Varshney, U]]
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[[Category: Varshney U]]
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[[Category: Vijayan, M]]
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[[Category: Vijayan M]]
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[[Category: Cytosol]]
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[[Category: Hydrolase]]
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[[Category: Hydrolysis of peptidyl-trna]]
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[[Category: Peptidyl-trna]]
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[[Category: Pth]]
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Current revision

Crystal structures of Peptidyl-tRNA hydrolase from Mycobacterium tuberculosis - Form 2 grown in presence of Pentaglycine

PDB ID 3tcn

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