1r6j
From Proteopedia
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'''Ultrahigh resolution Crystal Structure of syntenin PDZ2''' | '''Ultrahigh resolution Crystal Structure of syntenin PDZ2''' | ||
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[[Category: Devedjiev, Y.]] | [[Category: Devedjiev, Y.]] | ||
[[Category: Kang, B S.]] | [[Category: Kang, B S.]] | ||
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Revision as of 04:08, 3 May 2008
Ultrahigh resolution Crystal Structure of syntenin PDZ2
Overview
The crystal structure of the second PDZ domain of the scaffolding protein syntenin was solved using data extending to 0.73 A resolution. The crystallographic model, including the hydrogen atoms and the anisotropic displacement parameters, was refined to a conventional R-factor of 7.5% and Rfree of 8.7%, making it the most precise crystallographic model of a protein molecule to date. The model reveals discrete disorder in several places in the molecule, and significant plasticity of the peptide bond, with some omega angles deviating by nearly 20 degrees from planarity. Most hydrogen atoms are easily identifiable in the electron density and weak hydrogen bonds of the C-H...O type are clearly visible between the beta-strands. The study sets a new standard for high-resolution protein crystallography.
About this Structure
1R6J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The PDZ2 domain of syntenin at ultra-high resolution: bridging the gap between macromolecular and small molecule crystallography., Kang BS, Devedjiev Y, Derewenda U, Derewenda ZS, J Mol Biol. 2004 Apr 30;338(3):483-93. PMID:15081807 Page seeded by OCA on Sat May 3 07:08:33 2008
