3vir

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Current revision (08:40, 20 March 2024) (edit) (undo)
 
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<StructureSection load='3vir' size='340' side='right'caption='[[3vir]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='3vir' size='340' side='right'caption='[[3vir]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3vir]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VIR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3vir]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VIR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3viq|3viq]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">swi5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vir OCA], [https://pdbe.org/3vir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vir RCSB], [https://www.ebi.ac.uk/pdbsum/3vir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vir ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vir OCA], [https://pdbe.org/3vir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vir RCSB], [https://www.ebi.ac.uk/pdbsum/3vir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vir ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SWI5_SCHPO SWI5_SCHPO]] Required for normal mating-type switching. Also involved in the rhp51-dependent recombination DNA repair pathway.<ref>PMID:14663140</ref>
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[https://www.uniprot.org/uniprot/SWI5_SCHPO SWI5_SCHPO] Required for normal mating-type switching. Also involved in the rhp51-dependent recombination DNA repair pathway.<ref>PMID:14663140</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Rad51 forms a helical filament on single-stranded DNA and promotes strand exchange between two homologous DNA molecules during homologous recombination. The Swi5-Sfr1 complex interacts directly with Rad51 and stimulates strand exchange. Here we describe structural and functional aspects of the complex. Swi5 and the C-terminal core domain of Sfr1 form an essential activator complex with a parallel coiled-coil heterodimer joined firmly together via two previously uncharacterized leucine-zipper motifs and a bundle. The resultant coiled coil is sharply kinked, generating an elongated crescent-shaped structure suitable for transient binding within the helical groove of the Rad51 filament. The N-terminal region of Sfr1, meanwhile, has an interface for binding of Rad51. Our data suggest that the snug fit resulting from the complementary geometry of the heterodimer activates the Rad51 filament and that the N-terminal domain of Sfr1 plays a role in the efficient recruitment of the Swi5-Sfr1 complex to the Rad51 filaments.
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Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex.,Kuwabara N, Murayama Y, Hashimoto H, Kokabu Y, Ikeguchi M, Sato M, Mayanagi K, Tsutsui Y, Iwasaki H, Shimizu T Structure. 2012 Mar 7;20(3):440-9. PMID:22405003<ref>PMID:22405003</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3vir" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fission yeast]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hashimoto, H]]
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[[Category: Schizosaccharomyces pombe 972h-]]
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[[Category: Iwasaki, H]]
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[[Category: Hashimoto H]]
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[[Category: Kuwabara, N]]
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[[Category: Iwasaki H]]
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[[Category: Sato, M]]
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[[Category: Kuwabara N]]
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[[Category: Shimizu, T]]
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[[Category: Sato M]]
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[[Category: Yamada, N]]
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[[Category: Shimizu T]]
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[[Category: Recombination activator]]
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[[Category: Yamada N]]
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[[Category: Sfr1]]
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Current revision

Crystal strcture of Swi5 from fission yeast

PDB ID 3vir

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