3vsk

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Current revision (08:41, 20 March 2024) (edit) (undo)
 
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<StructureSection load='3vsk' size='340' side='right'caption='[[3vsk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3vsk' size='340' side='right'caption='[[3vsk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3vsk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staaw Staaw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VSK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3vsk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MW2 Staphylococcus aureus subsp. aureus MW2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VSK FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vsl|3vsl]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.301&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pbp3, MW1504 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=196620 STAAW])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vsk OCA], [https://pdbe.org/3vsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vsk RCSB], [https://www.ebi.ac.uk/pdbsum/3vsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vsk ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vsk OCA], [https://pdbe.org/3vsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vsk RCSB], [https://www.ebi.ac.uk/pdbsum/3vsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vsk ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A0H3K0B9_STAAW A0A0H3K0B9_STAAW]
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Staphylococcus aureus is a widespread Gram-positive opportunistic pathogen, and a methicillin-resistant form (MRSA) is particularly difficult to treat clinically. We have solved two crystal structures of penicillin-binding protein (PBP) 3 (PBP3) from MRSA, the apo form and a complex with the beta-lactam antibiotic cefotaxime, and used electrospray mass spectrometry to measure its sensitivity to a variety of penicillin derivatives. PBP3 is a class B PBP, possessing an N-terminal non-penicillin-binding domain, sometimes called a dimerization domain, and a C-terminal transpeptidase domain. The model shows a different orientation of its two domains compared to earlier models of other class B PBPs and a novel, larger N-domain. Consistent with the nomenclature of "dimerization domain", the N-terminal region forms an apparently tight interaction with a neighboring molecule related by a 2-fold symmetry axis in the crystal structure. This dimer form is predicted to be highly stable in solution by the PISA server, but mass spectrometry and analytical ultracentrifugation provide unequivocal evidence that the protein is a monomer in solution.
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Crystal structures of penicillin-binding protein 3 (PBP3) from methicillin-resistant Staphylococcus aureus in the apo and cefotaxime-bound forms.,Yoshida H, Kawai F, Obayashi E, Akashi S, Roper DI, Tame JR, Park SY J Mol Biol. 2012 Oct 26;423(3):351-64. doi: 10.1016/j.jmb.2012.07.012. Epub 2012 , Jul 27. PMID:22846910<ref>PMID:22846910</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3vsk" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Staaw]]
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[[Category: Staphylococcus aureus subsp. aureus MW2]]
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[[Category: Park, S Y]]
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[[Category: Park SY]]
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[[Category: Tame, J R]]
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[[Category: Tame JR]]
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[[Category: Yoshida, H]]
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[[Category: Yoshida H]]
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[[Category: Penicillin-binding domain]]
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[[Category: Penicillin-binding protein]]
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[[Category: Transpeptidase]]
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Current revision

Crystal structure of penicillin-binding protein 3 (PBP3) from methicilin-resistant Staphylococcus aureus in the apo form.

PDB ID 3vsk

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OCA

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