3w8r

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Current revision (08:44, 20 March 2024) (edit) (undo)
 
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<StructureSection load='3w8r' size='340' side='right'caption='[[3w8r]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3w8r' size='340' side='right'caption='[[3w8r]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3w8r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W8R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3w8r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W8R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CTN:4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE'>CTN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3asy|3asy]], [[3w34|3w34]], [[3asz|3asz]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CTN:4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE'>CTN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TTHA0578, udk ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Uridine_kinase Uridine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.48 2.7.1.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w8r OCA], [https://pdbe.org/3w8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w8r RCSB], [https://www.ebi.ac.uk/pdbsum/3w8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w8r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w8r OCA], [https://pdbe.org/3w8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w8r RCSB], [https://www.ebi.ac.uk/pdbsum/3w8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w8r ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/URK_THET8 URK_THET8]
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Uridine-cytidine kinase (UCK), including human UCK2, are a family of enzymes that generally phosphorylate both uridine and cytidine. However, UCK of Thermus thermophilus HB8 (ttCK) phosphorylates only cytidine. This cytidine-restricted activity is thought to depend on Tyr93, although the precise mechanism remains unresolved. Exhaustive mutagenesis of Tyr93 in ttCK revealed that the uridine phosphorylation activity was restored only by replacement of Tyr93 with His or Gln. Replacement of His117 in human UCK2, corresponding to residue Tyr93 in ttCK, by Tyr resulted in a loss of uridine phosphorylation activity. These findings indicated that uridine phosphorylation activity commonly depends on a single residue in the UCK family.
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Indispensable residue for uridine binding in the uridine-cytidine kinase family.,Tomoike F, Nakagawa N, Fukui K, Yano T, Kuramitsu S, Masui R Biochem Biophys Rep. 2017 Jul 8;11:93-98. doi: 10.1016/j.bbrep.2017.07.002., eCollection 2017 Sep. PMID:28955773<ref>PMID:28955773</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3w8r" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Thet8]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Uridine kinase]]
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[[Category: Kuramitsu S]]
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[[Category: Kuramitsu, S]]
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[[Category: Masui R]]
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[[Category: Masui, R]]
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[[Category: Nakagawa N]]
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[[Category: Nakagawa, N]]
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[[Category: Tomoike F]]
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[[Category: Tomoike, F]]
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[[Category: Kinase]]
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[[Category: Transferase]]
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Current revision

Mutant structure of Thermus thermophilus HB8 uridine-cytidine kinase

PDB ID 3w8r

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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