3wkv

<table><tr><td colspan='2'>[[3wkv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WKV FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wkv OCA], [https://pdbe.org/3wkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wkv RCSB], [https://www.ebi.ac.uk/pdbsum/3wkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wkv ProSAT]</span></td></tr>

== Publication Abstract from PubMed ==

The voltage-gated proton channel Hv1 (or VSOP) has a voltage-sensor domain (VSD) with dual roles of voltage sensing and proton permeation. Its gating is sensitive to pH and Zn(2+). Here we present a crystal structure of mouse Hv1 in the resting state at 3.45-A resolution. The structure showed a 'closed umbrella' shape with a long helix consisting of the cytoplasmic coiled coil and the voltage-sensing helix, S4, and featured a wide inner-accessible vestibule. Two out of three arginines in S4 were located below the phenylalanine constituting the gating charge-transfer center. The extracellular region of each protomer coordinated a Zn(2+), thus suggesting that Zn(2+) stabilizes the resting state of Hv1 by competing for acidic residues that otherwise form salt bridges with voltage-sensing positive charges on S4. These findings provide a platform for understanding the general principles of voltage sensing and proton permeation.

 

X-ray crystal structure of voltage-gated proton channel.,Takeshita K, Sakata S, Yamashita E, Fujiwara Y, Kawanabe A, Kurokawa T, Okochi Y, Matsuda M, Narita H, Okamura Y, Nakagawa A Nat Struct Mol Biol. 2014 Apr;21(4):352-7. doi: 10.1038/nsmb.2783. Epub 2014 Mar , 2. PMID:24584463<ref>PMID:24584463</ref>

 

== References ==

<references/>

[[Category: Lk3 transgenic mice]]

[[Category: Fujiwara, Y]]

[[Category: Kawanabe, A]]

[[Category: Kurokawa, T]]

[[Category: Matsuda, M]]

[[Category: Nakagawa, A]]

[[Category: Narita, H]]

[[Category: Okamura, Y]]

[[Category: Okochi, Y]]

[[Category: Sakata, S]]

[[Category: Takeshita, K]]

[[Category: Yamashita, E]]

[[Category: Transmembrane helix/helix/membrane protein]]