3wq9

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Current revision (08:46, 20 March 2024) (edit) (undo)
 
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<StructureSection load='3wq9' size='340' side='right'caption='[[3wq9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='3wq9' size='340' side='right'caption='[[3wq9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wq9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WQ9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wq9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WQ9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YUK:2-[(TRANS-4-HYDROXYCYCLOHEXYL)AMINO]-4-[5-(4-PHENYL-1H-IMIDAZOL-1-YL)ISOQUINOLIN-1-YL]BENZAMIDE'>YUK</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YUK:2-[(TRANS-4-HYDROXYCYCLOHEXYL)AMINO]-4-[5-(4-PHENYL-1H-IMIDAZOL-1-YL)ISOQUINOLIN-1-YL]BENZAMIDE'>YUK</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wq9 OCA], [https://pdbe.org/3wq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wq9 RCSB], [https://www.ebi.ac.uk/pdbsum/3wq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wq9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wq9 OCA], [https://pdbe.org/3wq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wq9 RCSB], [https://www.ebi.ac.uk/pdbsum/3wq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wq9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chong, K T]]
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[[Category: Chong KT]]
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[[Category: Kitade, M]]
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[[Category: Kitade M]]
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[[Category: Oshiumi, H]]
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[[Category: Oshiumi H]]
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[[Category: Uno, T]]
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[[Category: Uno T]]
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[[Category: Yamashita, S]]
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[[Category: Yamashita S]]
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[[Category: Atp binding]]
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[[Category: Chaperone]]
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[[Category: Hydrolase]]
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Current revision

Crystal structure of Hsp90-alpha N-terminal domain in complex with 2-(4-Hydroxy-cyclohexylamino)-4-[5-(4-phenyl-imidazol-1-yl)-isoquinolin-1-yl]-benzamide

PDB ID 3wq9

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