4r3q
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4r3q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R3Q FirstGlance]. <br> | <table><tr><td colspan='2'>[[4r3q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R3Q FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3q OCA], [https://pdbe.org/4r3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r3q RCSB], [https://www.ebi.ac.uk/pdbsum/4r3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3q ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.901Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3q OCA], [https://pdbe.org/4r3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r3q RCSB], [https://www.ebi.ac.uk/pdbsum/4r3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3q ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/SYCE3_MOUSE SYCE3_MOUSE] Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility. May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism.<ref>PMID:20407872</ref> <ref>PMID:21637789</ref> | [https://www.uniprot.org/uniprot/SYCE3_MOUSE SYCE3_MOUSE] Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility. May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism.<ref>PMID:20407872</ref> <ref>PMID:21637789</ref> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The key step in meiosis is synaptonemal complex formation, which mediates homologous chromosome alignment and synapsis. False pairing between homologous chromosomes produces infertility. Here, we present a crystal structure of the mouse meiosis-specific protein SYCE3, which is a component of the synaptonemal complex central element. Our studies show that functional SYCE3 most likely forms a dimer or higher order oligomer in cells. Furthermore, we demonstrate that the SYCE3 N-helix interacts with the SYCE1 C-helix, which is another central element component. Our results suggest that helical packing may mediate intra- or inter-association of each central element protein component, thereby playing an essential role in forming the synaptonemal complex central elements. | ||
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| - | Structural insight into the central element assembly of the synaptonemal complex.,Lu J, Gu Y, Feng J, Zhou W, Yang X, Shen Y Sci Rep. 2014 Nov 14;4:7059. doi: 10.1038/srep07059. PMID:25394919<ref>PMID:25394919</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 4r3q" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Crystal structure of SYCE3
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Categories: Large Structures | Mus musculus | Feng J | Lu J | Shen Y | Yang X | Zhou W
