5i5n
From Proteopedia
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ML_THOGV ML_THOGV] Blocks host IRF3 and IRF7, thereby inhibiting IFN-beta expression and activation of host antiviral state.<ref>PMID:15582653</ref> <ref>PMID:18768974</ref> <ref>PMID:19812269</ref> | [https://www.uniprot.org/uniprot/ML_THOGV ML_THOGV] Blocks host IRF3 and IRF7, thereby inhibiting IFN-beta expression and activation of host antiviral state.<ref>PMID:15582653</ref> <ref>PMID:18768974</ref> <ref>PMID:19812269</ref> | ||
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| - | == Publication Abstract from PubMed == | ||
| - | The matrix proteins of orthomyxoviruses, including influenza virus, infectious salmon anemia virus and Thogoto virus, play crucial roles in essential processes of the viral life cycle. However, the mechanisms of the matrix proteins involved in these processes are not fully understood. Currently, only the structure and function of the matrix protein from influenza virus have been studied. Here, we present the crystal structures of the N-terminal domain of matrix protein from Thogoto virus at pH 7.0 and 4.5. By analyzing the structures, we identified the conformational changes of monomers and dimers in different pH conditions, mainly caused by two flexible loops, L3 and L5. We suggest these structural deviations would reflect the basis of viral capsid assembly or disassembly. | ||
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| - | Conformational changes of matrix protein from Thogoto virus at different pH implicate the mechanism of viral assembly and uncoating.,Yang M, Feng F, Liu Y, Wang H, Yang Z, Hou W, Liang H J Gen Virol. 2016 Jul 13. doi: 10.1099/jgv.0.000551. PMID:27411929<ref>PMID:27411929</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
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| - | <div class="pdbe-citations 5i5n" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Crystal Structure of N-terminal Domain of Matrix Protein of Thogoto Virus at Acidic pH.
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