5wxl

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Current revision (09:19, 20 March 2024) (edit) (undo)
 
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<StructureSection load='5wxl' size='340' side='right'caption='[[5wxl]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5wxl' size='340' side='right'caption='[[5wxl]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5wxl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WXL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WXL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5wxl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WXL FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wxl OCA], [http://pdbe.org/5wxl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wxl RCSB], [http://www.ebi.ac.uk/pdbsum/5wxl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wxl ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wxl OCA], [https://pdbe.org/5wxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wxl RCSB], [https://www.ebi.ac.uk/pdbsum/5wxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wxl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RPF2_YEAST RPF2_YEAST]] Required for biogenesis of the 60S ribosomal subunit.<ref>PMID:12702244</ref> [[http://www.uniprot.org/uniprot/RRS1_YEAST RRS1_YEAST]] Required for ribosome biogenesis.<ref>PMID:10688653</ref>
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[https://www.uniprot.org/uniprot/RPF2_YEAST RPF2_YEAST] Required for biogenesis of the 60S ribosomal subunit.<ref>PMID:12702244</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Eukaryotic small ribosomal subunits are first assembled into 90S pre-ribosomes. The complete 90S is a gigantic complex with a molecular mass of approximately five megadaltons. Here, we report the nearly complete architecture of Saccharomyces cerevisiae 90S determined from three cryo-electron microscopy single particle reconstructions at 4.5 to 8.7 angstrom resolution. The majority of the density maps were modeled and assigned to specific RNA and protein components. The nascent ribosome is assembled into isolated native-like substructures that are stabilized by abundant assembly factors. The 5' external transcribed spacer and U3 snoRNA nucleate a large subcomplex that scaffolds the nascent ribosome. U3 binds four sites of pre-rRNA, including a novel site on helix 27 but not the 3' side of the central pseudoknot, and crucially organizes the 90S structure. The 90S model provides significant insight into the principle of small subunit assembly and the function of assembly factors.
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Molecular architecture of the 90S small subunit pre-ribosome.,Sun Q, Zhu X, Qi J, An W, Lan P, Tan D, Chen R, Wang B, Zheng S, Zhang C, Chen X, Zhang W, Chen J, Dong MQ, Ye K Elife. 2017 Feb 28;6. pii: e22086. doi: 10.7554/eLife.22086. PMID:28244370<ref>PMID:28244370</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5wxl" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Ribosome biogenesis protein|Ribosome biogenesis protein]]
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*[[Ribosome biogenesis protein 3D structures|Ribosome biogenesis protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ye, K]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Zheng, S]]
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[[Category: Ye K]]
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[[Category: Components of 90s preribosome]]
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[[Category: Zheng S]]
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[[Category: Nuclear protein]]
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[[Category: Protein complex]]
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Current revision

Crystal structure of the Rrs1 and Rpf2 complex

PDB ID 5wxl

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