6ojn

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Current revision (09:24, 20 March 2024) (edit) (undo)
 
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<SX load='6ojn' size='340' side='right' viewer='molstar' caption='[[6ojn]], [[Resolution|resolution]] 8.60&Aring;' scene=''>
<SX load='6ojn' size='340' side='right' viewer='molstar' caption='[[6ojn]], [[Resolution|resolution]] 8.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ojn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Singapore_grouper_iridovirus Singapore grouper iridovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OJN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6OJN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ojn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Singapore_grouper_iridovirus Singapore grouper iridovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OJN FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ojn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ojn OCA], [http://pdbe.org/6ojn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ojn RCSB], [http://www.ebi.ac.uk/pdbsum/6ojn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ojn ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ojn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ojn OCA], [https://pdbe.org/6ojn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ojn RCSB], [https://www.ebi.ac.uk/pdbsum/6ojn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ojn ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q5YFJ3_9VIRU Q5YFJ3_9VIRU]
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SGIV, or Singapore grouper iridovirus, is a large double-stranded DNA virus, reaching a diameter of 220 nm and packaging a genome of 140 kb. We present a 3D cryoelectron microscopy (cryo-EM) icosahedral reconstruction of SGIV determined at 8.6-A resolution. It reveals several layers including a T = 247 icosahedral outer coat, anchor proteins, a lipid bilayer, and the encapsidated DNA. A new segmentation tool, iSeg, was applied to extract these layers from the reconstructed map. The outer coat was further segmented into major and minor capsid proteins. None of the proteins extracted by segmentation have known atomic structures. We generated models for the major coat protein using three comparative modeling tools, and evaluated each model using the cryo-EM map. Our analysis reveals a new architecture in the Iridoviridae family of viruses. It shares similarities with others in the same family, e.g., Chilo iridescent virus, but also shows new features of the major and minor capsid proteins.
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Segmentation and Comparative Modeling in an 8.6-A Cryo-EM Map of the Singapore Grouper Iridovirus.,Pintilie G, Chen DH, Tran BN, Jakana J, Wu J, Hew CL, Chiu W Structure. 2019 Oct 1;27(10):1561-1569.e4. doi: 10.1016/j.str.2019.08.002. Epub, 2019 Aug 22. PMID:31447288<ref>PMID:31447288</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6ojn" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Singapore grouper iridovirus]]
[[Category: Singapore grouper iridovirus]]
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[[Category: Chen, D H]]
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[[Category: Chen D-H]]
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[[Category: Chiu, W]]
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[[Category: Chiu W]]
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[[Category: Hew, C L]]
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[[Category: Hew CL]]
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[[Category: Jakana, J]]
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[[Category: Jakana J]]
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[[Category: Pintilie, G]]
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[[Category: Pintilie G]]
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[[Category: Tran, B N]]
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[[Category: Tran BN]]
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[[Category: Wu, J]]
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[[Category: Wu J]]
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[[Category: Anchor protein]]
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[[Category: Icosahedral]]
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[[Category: Outer coat]]
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[[Category: Trimer]]
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[[Category: Viral protein]]
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[[Category: Zip protein]]
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Current revision

Comparative Model of SGIV Major Coat Protein (MCP) Trimer Based on Cryo-EM Map

6ojn, resolution 8.60Å

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OCA

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