6ouu

<table><tr><td colspan='2'>[[6ouu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Norovirus_hu/gii.4/minerva/2006/usa Norovirus hu/gii.4/minerva/2006/usa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OUU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6OUU FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6otf|6otf]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ouu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ouu OCA], [http://pdbe.org/6ouu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ouu RCSB], [http://www.ebi.ac.uk/pdbsum/6ouu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ouu ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Noroviruses are a leading cause of foodborne illnesses worldwide. Although GII.4 strains have been responsible for most norovirus outbreaks, the assembled virus shell structures have been available in detail for only a single strain (GI.1). We present high-resolution (2.6- to 4.1-A) cryoelectron microscopy (cryo-EM) structures of GII.4, GII.2, GI.7, and GI.1 human norovirus outbreak strain virus-like particles (VLPs). Although norovirus VLPs have been thought to exist in a single-sized assembly, our structures reveal polymorphism between and within genogroups, with small, medium, and large particle sizes observed. Using asymmetric reconstruction, we were able to resolve a Zn(2+) metal ion adjacent to the coreceptor binding site, which affected the structural stability of the shell. Our structures serve as valuable templates for facilitating vaccine formulations.

 

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== References ==

[[Category: Norovirus hu/gii 4/minerva/2006/usa]]

[[Category: Diehnelt, C W]]

[[Category: Grant, T]]

[[Category: Grigorieff, N]]

[[Category: Joshua-Tor, L]]

[[Category: Jung, J]]

[[Category: Thomas, D R]]

[[Category: Virus like particle]]