6pvl

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Current revision (09:27, 20 March 2024) (edit) (undo)
 
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<SX load='6pvl' size='340' side='right' viewer='molstar' caption='[[6pvl]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
<SX load='6pvl' size='340' side='right' viewer='molstar' caption='[[6pvl]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6pvl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PVL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6PVL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6pvl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PVL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Trpv3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6pvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pvl OCA], [http://pdbe.org/6pvl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pvl RCSB], [http://www.ebi.ac.uk/pdbsum/6pvl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pvl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pvl OCA], [https://pdbe.org/6pvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pvl RCSB], [https://www.ebi.ac.uk/pdbsum/6pvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pvl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE]] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).
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[https://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first step, sensitization, the channel pore remains closed while S6 helices undergo alpha-to-pi transitions. During the weakly temperature-dependent second step, channel opening, tight association of the S1-S4 and pore domains is stabilized by changes in the carboxy-terminal and linker domains.
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Structural basis of temperature sensation by the TRP channel TRPV3.,Singh AK, McGoldrick LL, Demirkhanyan L, Leslie M, Zakharian E, Sobolevsky AI Nat Struct Mol Biol. 2019 Oct 21. pii: 10.1038/s41594-019-0318-7. doi:, 10.1038/s41594-019-0318-7. PMID:31636415<ref>PMID:31636415</ref>
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6pvl" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: McGoldrick, L L]]
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[[Category: McGoldrick LL]]
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[[Category: Singh, A K]]
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[[Category: Singh AK]]
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[[Category: Sobolevsky, A I]]
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[[Category: Sobolevsky AI]]
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[[Category: Ion channel]]
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[[Category: Membrane protein]]
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[[Category: Transport protein]]
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[[Category: Trp channel]]
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Current revision

Cryo-EM structure of mouse TRPV3 in closed state at 42 degrees Celsius

6pvl, resolution 4.40Å

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OCA

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