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1e09
From Proteopedia
(Difference between revisions)
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==Solution Structure of the Major Cherry Allergen Pru av 1== | ==Solution Structure of the Major Cherry Allergen Pru av 1== | ||
| - | <StructureSection load='1e09' size='340' side='right'caption='[[1e09 | + | <StructureSection load='1e09' size='340' side='right'caption='[[1e09]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1e09]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1e09]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Prunus_avium Prunus avium]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E09 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e09 OCA], [https://pdbe.org/1e09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e09 RCSB], [https://www.ebi.ac.uk/pdbsum/1e09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e09 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e09 OCA], [https://pdbe.org/1e09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e09 RCSB], [https://www.ebi.ac.uk/pdbsum/1e09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e09 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PRU1_PRUAV PRU1_PRUAV] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e09 ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e09 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Birch pollinosis is often accompanied by hypersensitivity to fruit as a consequence of the cross-reaction of pollen allergen-specific IgE antibodies with homologous food proteins. To provide a basis for examining the cross-reactivity on a structural level, we used heteronuclear multidimensional NMR spectroscopy to determine the high-resolution three-dimensional structure of the major cherry allergen, Pru av 1, in solution. Based on a detailed comparison of the virtually identical structures of Pru av 1 and Bet v 1, the major birch pollen allergen, we propose an explanation for a significant aspect of the observed cross-reactivity pattern among the family of allergens under consideration. The large hydrophobic cavity expected to be important for the still unknown physiological function of Bet v 1 is conserved in Pru av 1. Structural homology to a domain of human MLN64 associated with cholesterol transport suggests phytosteroids as putative ligands for Pru av 1. NMR spectroscopy provides experimental evidence that Pru av 1 interacts with phytosteroids, and molecular modeling shows that the hydrophobic cavity is large enough to accommodate two such molecules. | ||
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| - | Allergic cross-reactivity made visible: solution structure of the major cherry allergen Pru av 1.,Neudecker P, Schweimer K, Nerkamp J, Scheurer S, Vieths S, Sticht H, Rosch P J Biol Chem. 2001 Jun 22;276(25):22756-63. Epub 2001 Apr 3. PMID:11287426<ref>PMID:11287426</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1e09" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Cerasus avium]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Boehm | + | [[Category: Prunus avium]] |
| - | [[Category: Nerkamp | + | [[Category: Boehm M]] |
| - | [[Category: Neudecker | + | [[Category: Nerkamp J]] |
| - | [[Category: Roesch | + | [[Category: Neudecker P]] |
| - | [[Category: Scheurer | + | [[Category: Roesch P]] |
| - | [[Category: Schweimer | + | [[Category: Scheurer S]] |
| - | [[Category: Sticht | + | [[Category: Schweimer K]] |
| - | [[Category: Vieths | + | [[Category: Sticht H]] |
| - | + | [[Category: Vieths S]] | |
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Revision as of 09:56, 20 March 2024
Solution Structure of the Major Cherry Allergen Pru av 1
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Categories: Large Structures | Prunus avium | Boehm M | Nerkamp J | Neudecker P | Roesch P | Scheurer S | Schweimer K | Sticht H | Vieths S
