1r8o
From Proteopedia
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'''Crystal structure of an unusual Kunitz-type trypsin inhibitor from Copaifera langsdorffii seeds''' | '''Crystal structure of an unusual Kunitz-type trypsin inhibitor from Copaifera langsdorffii seeds''' | ||
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[[Category: Polikarpov, I.]] | [[Category: Polikarpov, I.]] | ||
[[Category: Silva, J A.da.]] | [[Category: Silva, J A.da.]] | ||
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| - | [[Category: | + | [[Category: Copaifera langsdorffii]] |
| - | [[Category: | + | [[Category: X-ray structure]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:13:21 2008'' | |
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Revision as of 04:13, 3 May 2008
Crystal structure of an unusual Kunitz-type trypsin inhibitor from Copaifera langsdorffii seeds
Overview
The crystallographic structure of a novel trypsin inhibitor (CTI) from Copaifera langsdorffii is reported. The structure was solved by MIRAS procedure and refined to a crystallographic residual of 17.3% (R(free) = 20.3%) at 1.8 A resolution. Two isomorphous derivatives were obtained by quick cryo-soaking approach. CTI is the first structure of a member of Kunitz (STI) family formed by two noncovalently bound polypeptide chains and only one disulfide bridge. A standard Kunitz-type inhibitor has a single polypeptide chain and two disulfide bridges. Structural features granting CTI high inhibitory activity are discussed.
About this Structure
1R8O is a Protein complex structure of sequences from Copaifera langsdorffii. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of an unusual Kunitz (STI) type trypsin inhibitor from Copaifera langsdorffii., Krauchenco S, Nagem RA, da Silva JA, Marangoni S, Polikarpov I, Biochimie. 2004 Mar;86(3):167-72. PMID:15134830 Page seeded by OCA on Sat May 3 07:13:21 2008
