1ed7

<StructureSection load='1ed7' size='340' side='right'caption='[[1ed7]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1ed7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_24 Atcc 24]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ED7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ED7 FirstGlance]. <br>

</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>

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== Publication Abstract from PubMed ==

The three-dimensional structure of the chitin-binding domain (ChBD) of chitinase A1 (ChiA1) from a Gram-positive bacterium, Bacillus circulans WL-12, was determined by means of multidimensional heteronuclear NMR methods. ChiA1 is a glycosidase that hydrolyzes chitin and is composed of an N-terminal catalytic domain, two fibronectin type III-like domains, and C-terminal ChBD(ChiA1) (45 residues, Ala(655)-Gln(699)), which binds specifically to insoluble chitin. ChBD(ChiA1) has a compact and globular structure with the topology of a twisted beta-sandwich. This domain contains two antiparallel beta-sheets, one composed of three strands and the other of two strands. The core region formed by the hydrophobic and aromatic residues makes the overall structure rigid and compact. The overall topology of ChBD(ChiA1) is similar to that of the cellulose-binding domain (CBD) of Erwinia chrysanthemi endoglucanase Z (CBD(EGZ)). However, ChBD(ChiA1) lacks the three aromatic residues aligned linearly and exposed to the solvent, which probably interact with cellulose in CBDs. Therefore, the binding mechanism of a group of ChBDs including ChBD(ChiA1) may be different from that proposed for CBDs.

Solution structure of the chitin-binding domain of Bacillus circulans WL-12 chitinase A1.,Ikegami T, Okada T, Hashimoto M, Seino S, Watanabe T, Shirakawa M J Biol Chem. 2000 May 5;275(18):13654-61. PMID:10788483<ref>PMID:10788483</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1ed7" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Atcc 24]]

[[Category: Chitinase]]

[[Category: Hashimoto, M]]

[[Category: Ikegami, T]]

[[Category: Okada, T]]

[[Category: Seino, S]]

[[Category: Shirakawa, M]]

[[Category: Watanabe, T]]

[[Category: Twisted beta-sandwich]]