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1tou

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(New page: 200px<br /> <applet load="1tou" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tou, resolution 2.00&Aring;" /> '''Crystal structure o...)
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Revision as of 17:20, 12 November 2007

Image:1tou.gif

1tou, resolution 2.00Å

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Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand

Overview

The synthesis and biological evaluation of novel human A-FABP inhibitors, based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is, described. Two series of compounds, bearing either an amino or carbon, substituent in the 2-position of the pyrimidine ring were investigated., Modification of substituents and chain length optimization led to novel, compounds with low micromolar activity and good selectivity for human, A-FABP.

About this Structure

1TOU is a Single protein structure of sequence from Homo sapiens with B1V as ligand. Full crystallographic information is available from OCA.

Reference

Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors., Ringom R, Axen E, Uppenberg J, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52. PMID:15357970

Page seeded by OCA on Mon Nov 12 19:26:27 2007

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