1r9g
From Proteopedia
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'''Three-dimensional Structure of YaaE from Bacillus subtilis''' | '''Three-dimensional Structure of YaaE from Bacillus subtilis''' | ||
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[[Category: Bennett, E M.]] | [[Category: Bennett, E M.]] | ||
[[Category: Ealick, S E.]] | [[Category: Ealick, S E.]] | ||
| - | [[Category: | + | [[Category: Alpha/beta protein]] |
| - | [[Category: | + | [[Category: Cofactor biosynthesis]] |
| - | [[Category: | + | [[Category: Glutaminase]] |
| - | [[Category: | + | [[Category: Triad amidotransferase]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:14:16 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 04:14, 3 May 2008
Three-dimensional Structure of YaaE from Bacillus subtilis
Overview
The structure of YaaE from Bacillus subtilis was determined at 2.5-A resolution. YaaE is a member of the triad glutamine aminotransferase family and functions in a recently identified alternate pathway for the biosynthesis of vitamin B(6). Proposed active residues include conserved Cys-79, His-170, and Glu-172. YaaE shows similarity to HisH, a glutaminase involved in histidine biosynthesis. YaaD associates with YaaE. A homology model of this protein was constructed. YaaD is predicted to be a (beta/alpha)(8) barrel on the basis of sequence comparisons. The predicted active site includes highly conserved residues 211-216 and 233-235. Finally, a homology model of a putative YaaD-YaaE complex was prepared using the structure of HisH-F as a model. This model predicts that the ammonia molecule generated by YaaE is channeled through the center of the YaaD barrel to the putative YaaD active site.
About this Structure
1R9G is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of YaaE from Bacillus subtilis, a glutaminase implicated in pyridoxal-5'-phosphate biosynthesis., Bauer JA, Bennett EM, Begley TP, Ealick SE, J Biol Chem. 2004 Jan 23;279(4):2704-11. Epub 2003 Oct 28. PMID:14585832 Page seeded by OCA on Sat May 3 07:14:16 2008
