1f9s
From Proteopedia
(Difference between revisions)
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<StructureSection load='1f9s' size='340' side='right'caption='[[1f9s]], [[Resolution|resolution]] 2.38Å' scene=''> | <StructureSection load='1f9s' size='340' side='right'caption='[[1f9s]], [[Resolution|resolution]] 2.38Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1f9s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1f9s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F9S FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38Å</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f9s OCA], [https://pdbe.org/1f9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f9s RCSB], [https://www.ebi.ac.uk/pdbsum/1f9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f9s ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f9s OCA], [https://pdbe.org/1f9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f9s RCSB], [https://www.ebi.ac.uk/pdbsum/1f9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f9s ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/PLF4_HUMAN PLF4_HUMAN] Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.<ref>PMID:7644496</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Aster | + | [[Category: Aster R]] |
| - | [[Category: Doyle | + | [[Category: Doyle M]] |
| - | [[Category: Edwards | + | [[Category: Edwards B]] |
| - | [[Category: Faulk | + | [[Category: Faulk T]] |
| - | [[Category: Visentin | + | [[Category: Visentin G]] |
| - | [[Category: Yang | + | [[Category: Yang J]] |
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Revision as of 10:12, 20 March 2024
CRYSTAL STRUCTURE OF PLATELET FACTOR 4 MUTANT 2
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Categories: Homo sapiens | Large Structures | Aster R | Doyle M | Edwards B | Faulk T | Visentin G | Yang J
