1fhs
From Proteopedia
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==THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY DOMAIN-2 OF THE GROWTH FACTOR RECEPTOR BOUND PROTEIN-2, NMR, 18 STRUCTURES== | ==THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY DOMAIN-2 OF THE GROWTH FACTOR RECEPTOR BOUND PROTEIN-2, NMR, 18 STRUCTURES== | ||
| - | <StructureSection load='1fhs' size='340' side='right'caption='[[1fhs | + | <StructureSection load='1fhs' size='340' side='right'caption='[[1fhs]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1fhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1fhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FHS FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fhs OCA], [https://pdbe.org/1fhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fhs RCSB], [https://www.ebi.ac.uk/pdbsum/1fhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fhs ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fhs OCA], [https://pdbe.org/1fhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fhs RCSB], [https://www.ebi.ac.uk/pdbsum/1fhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fhs ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Black | + | [[Category: Black S]] |
| - | [[Category: Frederick | + | [[Category: Frederick AF]] |
| - | [[Category: Perkins | + | [[Category: Perkins LM]] |
| - | [[Category: Senior | + | [[Category: Senior MM]] |
| - | [[Category: Snow | + | [[Category: Snow ME]] |
| - | [[Category: Wang | + | [[Category: Wang Y-S]] |
| - | [[Category: Wilson | + | [[Category: Wilson O]] |
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Revision as of 10:14, 20 March 2024
THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY DOMAIN-2 OF THE GROWTH FACTOR RECEPTOR BOUND PROTEIN-2, NMR, 18 STRUCTURES
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Categories: Homo sapiens | Large Structures | Black S | Frederick AF | Perkins LM | Senior MM | Snow ME | Wang Y-S | Wilson O
