Penams
From Proteopedia
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<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='10/1038837/Cv/1'> | <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='10/1038837/Cv/1'> | ||
| - | Penams are the primary skeleton structures that define the penicillin subclass of the broader β-lactam family of antibiotics and related compounds. They are bicyclic ring systems containing a β-lactam moiety fused with a five-member thiazolidine ring.<ref name="a1">PMID:16942059</ref> Due to ring strain and limitations on amide resonance, the structure is unstable and highly susceptible to catalytic cleavage at the amide bond.<ref>doi:10.1093/actrade/9780198759775.003.0005</ref> Benzylpenicillin (penicillin G) is the natural product parent that contains the penam structure. See also [https://en.wikipedia.org/wiki/Penam Penam]. | + | Penams are the primary skeleton structures that define the penicillin subclass of the broader β-lactam family of antibiotics and related compounds. They are bicyclic ring systems containing a β-lactam moiety fused with a five-member thiazolidine ring.<ref name="a1">PMID:16942059</ref> Due to ring strain and limitations on amide resonance, the structure is unstable and highly susceptible to catalytic cleavage at the amide bond.<ref>doi:10.1093/actrade/9780198759775.003.0005</ref> <scene name='10/1038837/Cv/2'>Benzylpenicillin (penicillin G)</scene> is the natural product parent that contains the penam structure. See also [https://en.wikipedia.org/wiki/Penam Penam]. |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 14:39, 21 March 2024
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References
- ↑ Novak I, Chua PJ. Computational study of pharmacophores: beta-lactams. J Phys Chem A. 2006 Sep 7;110(35):10521-4. PMID:16942059 doi:10.1021/jp063162b
- ↑ doi: https://dx.doi.org/10.1093/actrade/9780198759775.003.0005
