8iqt

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m (Protected "8iqt" [edit=sysop:move=sysop])
Current revision (10:08, 27 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8iqt is ON HOLD
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==Crystal structure of the human vitamin D receptor ligand binding domain complexed with (23R)-F-25(OH)D3==
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<StructureSection load='8iqt' size='340' side='right'caption='[[8iqt]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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Authors: Kakuda, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8iqt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IQT FirstGlance]. <br>
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Description: Crystal structure of the human vitamin D receptor ligand binding domain complexed with (23R)-F-25(OH)D3
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.745&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SV0:(1~{S},3~{Z})-3-[(2~{E})-2-[(1~{R},3~{a}~{S},7~{a}~{R})-1-[(2~{R},4~{R})-4-fluoranyl-6-methyl-6-oxidanyl-heptan-2-yl]-7~{a}-methyl-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol'>SV0</scene></td></tr>
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[[Category: Kakuda, S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iqt OCA], [https://pdbe.org/8iqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iqt RCSB], [https://www.ebi.ac.uk/pdbsum/8iqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iqt ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN] Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:[https://omim.org/entry/277440 277440]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.<ref>PMID:2849209</ref> <ref>PMID:8381803</ref> <ref>PMID:1652893</ref> <ref>PMID:2177843</ref> <ref>PMID:8106618</ref> <ref>PMID:8392085</ref> <ref>PMID:7828346</ref> <ref>PMID:8675579</ref> <ref>PMID:8961271</ref> <ref>PMID:9005998</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:16252006</ref> <ref>PMID:10678179</ref> <ref>PMID:15728261</ref> <ref>PMID:16913708</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Kakuda S]]

Current revision

Crystal structure of the human vitamin D receptor ligand binding domain complexed with (23R)-F-25(OH)D3

PDB ID 8iqt

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