8os5
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Factor XII heavy chain reveals an interlocking dimer with a FnII to kringle domain interaction== | |
| - | + | <StructureSection load='8os5' size='340' side='right'caption='[[8os5]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8os5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OS5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8os5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8os5 OCA], [https://pdbe.org/8os5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8os5 RCSB], [https://www.ebi.ac.uk/pdbsum/8os5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8os5 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q8IZZ5_HUMAN Q8IZZ5_HUMAN] Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.[ARBA:ARBA00037517] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Brown A]] | ||
| + | [[Category: Emsley J]] | ||
| + | [[Category: Kaira BG]] | ||
| + | [[Category: Li C]] | ||
| + | [[Category: Philippou H]] | ||
| + | [[Category: Saleem M]] | ||
| + | [[Category: Wilson C]] | ||
Revision as of 10:10, 27 March 2024
Crystal structure of the Factor XII heavy chain reveals an interlocking dimer with a FnII to kringle domain interaction
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Categories: Homo sapiens | Large Structures | Brown A | Emsley J | Kaira BG | Li C | Philippou H | Saleem M | Wilson C
