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8qub
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Hexameric HIV-1 CA in complex with DDD00074110== | |
| - | + | <StructureSection load='8qub' size='340' side='right'caption='[[8qub]], [[Resolution|resolution]] 1.63Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8qub]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QUB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WVZ:(1~{S})-1-phenyl-2,4-dihydro-1~{H}-isoquinolin-3-one'>WVZ</scene></td></tr> |
| - | [[Category: Fyfe | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qub OCA], [https://pdbe.org/8qub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qub RCSB], [https://www.ebi.ac.uk/pdbsum/8qub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qub ProSAT]</span></td></tr> |
| - | [[Category: Petit | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human immunodeficiency virus 1]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fyfe PK]] | ||
| + | [[Category: Petit AP]] | ||
Current revision
Hexameric HIV-1 CA in complex with DDD00074110
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