8rqf

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'''Unreleased structure'''
 
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The entry 8rqf is ON HOLD until Paper Publication
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==Cryo-EM structure of human NTCP-Bulevirtide complex==
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<StructureSection load='8rqf' size='340' side='right'caption='[[8rqf]], [[Resolution|resolution]] 3.41&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8rqf]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Hepatitis_B_virus_genotype_C Hepatitis B virus genotype C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RQF FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.41&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BJU:N-tetradecanoylglycine'>BJU</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rqf OCA], [https://pdbe.org/8rqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rqf RCSB], [https://www.ebi.ac.uk/pdbsum/8rqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rqf ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN] As a major transporter of conjugated bile salts from plasma into the hepatocyte, it has a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Able to transport taurocholate, cholate, and the non-bile acid estron sulfate (PubMed:14660639, PubMed:24867799).<ref>PMID:14660639</ref> <ref>PMID:24867799</ref> (Microbial infection) Acts as a receptor for hepatitis B virus.<ref>PMID:23150796</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Hepatitis B virus genotype C]]
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[[Category: Homo sapiens]]
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[[Category: Lama glama]]
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[[Category: Large Structures]]
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[[Category: Bang-Soerensen R]]
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[[Category: Geyer J]]
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[[Category: Glebe D]]
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[[Category: Goldmann N]]
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[[Category: Irobalieva RN]]
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[[Category: Kossiakoff AA]]
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[[Category: Kunz S]]
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[[Category: Liu H]]
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[[Category: Locher KP]]
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[[Category: Mukherjee S]]
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[[Category: Nosol K]]
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[[Category: Rossi L]]
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[[Category: Urban S]]
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[[Category: Zakrzewicz D]]

Revision as of 10:12, 27 March 2024

Cryo-EM structure of human NTCP-Bulevirtide complex

PDB ID 8rqf

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