8sv9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:12, 27 March 2024) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8sv9 is ON HOLD until Paper Publication
+
==Crystal structure of ULK1 kinase domain with inhibitor MR-2088==
-
 
+
<StructureSection load='8sv9' size='340' side='right'caption='[[8sv9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
Authors: Schonbrunn, E., Sun, L.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8sv9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SV9 FirstGlance]. <br>
-
Description: Crystal structure of ULK1 kinase domain with inhibitor MR-2088
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=WXH:(4P)-4-[(2P)-2-(1,2,5,6-tetrahydropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-(2,2,2-trifluoroethyl)thiophene-2-carboxamide'>WXH</scene></td></tr>
-
[[Category: Schonbrunn, E]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sv9 OCA], [https://pdbe.org/8sv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sv9 RCSB], [https://www.ebi.ac.uk/pdbsum/8sv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sv9 ProSAT]</span></td></tr>
-
[[Category: Sun, L]]
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ULK1_HUMAN ULK1_HUMAN] Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.<ref>PMID:18936157</ref> <ref>PMID:21460634</ref> <ref>PMID:21795849</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Schonbrunn E]]
 +
[[Category: Sun L]]

Current revision

Crystal structure of ULK1 kinase domain with inhibitor MR-2088

PDB ID 8sv9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8sv9"
Personal tools