8u4w

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Current revision (10:13, 27 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8u4w is ON HOLD until Paper Publication
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==The crystal structure of a helical domain deleted PARP1 in complex with isoindolinone based inhibitor.==
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<StructureSection load='8u4w' size='340' side='right'caption='[[8u4w]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
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Authors: Marcotte, D.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8u4w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8U4W FirstGlance]. <br>
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Description: The crystal structure of a helical domain deleted PARP1 in complex with isoindolinone based inhibitor.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.02&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VHU:(4M)-4-(2-{4-[(3S)-1-acetylpiperidine-3-carbonyl]piperazine-1-carbonyl}-1-benzofuran-7-yl)-1H-isoindol-1-one'>VHU</scene></td></tr>
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[[Category: Marcotte, D.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8u4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u4w OCA], [https://pdbe.org/8u4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u4w RCSB], [https://www.ebi.ac.uk/pdbsum/8u4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u4w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Marcotte DJ]]

Current revision

The crystal structure of a helical domain deleted PARP1 in complex with isoindolinone based inhibitor.

PDB ID 8u4w

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