5xwg

<table><tr><td colspan='2'>[[5xwg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XWG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XWG FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xwg OCA], [http://pdbe.org/5xwg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xwg RCSB], [http://www.ebi.ac.uk/pdbsum/5xwg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xwg ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

We have determined a crystal structure of an RNA duplex containing a novel metal-binding motif. The motif is composed of two sheared GoA base pairs, two unpaired A residues and four phosphate groups in close proximity. Four A residues make an A-A-A-A stacking column at the minor groove side and two G bases are highly inclined, thereby forming the pocket-shaped motif at the major groove side. In the present structure, a hydrated Sr2+ ion exists in the pocket and binds to the O6 and N7 atoms of the two G bases and four phosphate groups. According to the previously-reported metal-binding properties to RNA molecules, many of divalent cations, such as Mg2+, Mn2+, Co2+, Zn2+, Ba2+, Pb2+ and Cd2+, may bind to the motif. This metal-binding motif can be used as a modular building block that allows for precise positioning of a single metal ion in functional nucleic acid molecules.

Crystal structure of a novel RNA motif that allows for precise positioning of a single metal ion.,Kanazawa H, Kondo J J Inorg Biochem. 2017 Nov;176:140-143. doi: 10.1016/j.jinorgbio.2017.08.029. Epub, 2017 Sep 21. PMID:28898762<ref>PMID:28898762</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Kanazawa, H]]

[[Category: Kondo, J]]

[[Category: Metal-ion-binding motif]]

[[Category: X-ray analysis]]