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5xyi

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Current revision (10:20, 27 March 2024) (edit) (undo)
 
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<SX load='5xyi' size='340' side='right' viewer='molstar' caption='[[5xyi]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
<SX load='5xyi' size='340' side='right' viewer='molstar' caption='[[5xyi]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5xyi]] is a 34 chain structure with sequence from [http://en.wikipedia.org/wiki/Trichomonas_vaginalis Trichomonas vaginalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XYI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XYI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5xyi]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichomonas_vaginalis Trichomonas vaginalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XYI FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xyi OCA], [http://pdbe.org/5xyi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xyi RCSB], [http://www.ebi.ac.uk/pdbsum/5xyi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xyi ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xyi OCA], [https://pdbe.org/5xyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xyi RCSB], [https://www.ebi.ac.uk/pdbsum/5xyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xyi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A2EFE7_TRIVA A2EFE7_TRIVA]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.[HAMAP-Rule:MF_03015]
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[https://www.uniprot.org/uniprot/A2EFE7_TRIV3 A2EFE7_TRIV3] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.[HAMAP-Rule:MF_03015]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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As an indispensable molecular machine universal in all living organisms, the ribosome has been selected by evolution to be the natural target of many antibiotics and small-molecule inhibitors. High-resolution structures of pathogen ribosomes are crucial for understanding the general and unique aspects of translation control in disease-causing microbes. With cryo-electron microscopy technique, we have determined structures of the cytosolic ribosomes from two human parasites, Trichomonas vaginalis and Toxoplasma gondii, at resolution of 3.2-3.4 A. Although the ribosomal proteins from both pathogens are typical members of eukaryotic families, with a co-evolution pattern between certain species-specific insertions/extensions and neighboring ribosomal RNA (rRNA) expansion segments, the sizes of their rRNAs are sharply different. Very interestingly, rRNAs of T. vaginalis are in size comparable to prokaryotic counterparts, with nearly all the eukaryote-specific rRNA expansion segments missing. These structures facilitate the dissection of evolution path for ribosomal proteins and RNAs, and may aid in design of novel translation inhibitors.Cell Research advance online publication 15 August 2017; doi:10.1038/cr.2017.104.
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Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii.,Li Z, Guo Q, Zheng L, Ji Y, Xie YT, Lai DH, Lun ZR, Suo X, Gao N Cell Res. 2017 Aug 15. doi: 10.1038/cr.2017.104. PMID:28809395<ref>PMID:28809395</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5xyi" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Receptor for activated protein kinase C 1|Receptor for activated protein kinase C 1]]
 
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
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== References ==
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*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
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<references/>
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__TOC__
__TOC__
</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Trichomonas vaginalis]]
[[Category: Trichomonas vaginalis]]
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[[Category: Gao, N]]
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[[Category: Gao N]]
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[[Category: Guo, Q]]
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[[Category: Guo Q]]
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[[Category: Ji, Y]]
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[[Category: Ji Y]]
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[[Category: Lai, D]]
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[[Category: Lai D]]
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[[Category: Li, Z]]
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[[Category: Li Z]]
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[[Category: Lun, Z]]
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[[Category: Lun Z]]
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[[Category: Suo, X]]
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[[Category: Suo X]]
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[[Category: Xie, Y]]
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[[Category: Xie Y]]
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[[Category: Zheng, L]]
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[[Category: Zheng L]]
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[[Category: Ribosome]]
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[[Category: Rprotein]]
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[[Category: Rrna]]
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[[Category: Trichomonas vaginalis ribosome]]
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Current revision

Small subunit of Trichomonas vaginalis ribosome

5xyi, resolution 3.35Å

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