5yda

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Current revision (10:22, 27 March 2024) (edit) (undo)
 
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<StructureSection load='5yda' size='340' side='right'caption='[[5yda]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='5yda' size='340' side='right'caption='[[5yda]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5yda]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YDA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5YDA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5yda]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp._CNQ431 Streptomyces sp. CNQ431]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YDA FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5yda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yda OCA], [http://pdbe.org/5yda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yda RCSB], [http://www.ebi.ac.uk/pdbsum/5yda PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yda ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.353&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yda OCA], [https://pdbe.org/5yda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yda RCSB], [https://www.ebi.ac.uk/pdbsum/5yda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yda ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A0E3JLZ0_9ACTN A0A0E3JLZ0_9ACTN]
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Polyketides are a large family of pharmaceutically important natural products, and the structural modification of their scaffolds is significant for drug development. Herein, we report high-resolution X-ray crystal structures of the broadly selective acyltransferase (AT) from the splenocin polyketide synthase (SpnD-AT) in the apo form and in complex with benzylmalonyl and pentynylmalonyl extender unit mimics. These structures revealed the molecular basis for the stereoselectivity and substrate specificity of SpnD-AT, and enabled the engineering of the industrially important Ery-AT6 to broaden its substrate scope to include three new types of extender units.
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Structural Basis of a Broadly Selective Acyltransferase from the Polyketide Synthase of Splenocin.,Li Y, Zhang W, Zhang H, Tian W, Wu L, Wang S, Zheng M, Zhang J, Sun C, Deng Z, Sun Y, Qu X, Zhou J Angew Chem Int Ed Engl. 2018 May 14;57(20):5823-5827. doi:, 10.1002/anie.201802805. Epub 2018 Apr 14. PMID:29536601<ref>PMID:29536601</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5yda" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Li, Y]]
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[[Category: Streptomyces sp. CNQ431]]
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[[Category: Qu, X D]]
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[[Category: Li Y]]
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[[Category: Zhou, J H]]
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[[Category: Qu XD]]
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[[Category: Acyl transferase domain]]
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[[Category: Zhou JH]]
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[[Category: Biosynthetic protein]]
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[[Category: Pk]]
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Current revision

The crystal structure of the Acyl Transferase domain of SpnD

PDB ID 5yda

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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