We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

5z2w

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:26, 27 March 2024) (edit) (undo)
 
Line 1: Line 1:
==Crystal structure of the bacterial cell division protein FtsQ and FtsB==
==Crystal structure of the bacterial cell division protein FtsQ and FtsB==
-
<StructureSection load='5z2w' size='340' side='right' caption='[[5z2w]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+
<StructureSection load='5z2w' size='340' side='right'caption='[[5z2w]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5z2w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z2W FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5z2w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z2W FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ftsQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895]), ftsB, AWP75_20790 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z2w OCA], [http://pdbe.org/5z2w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z2w RCSB], [http://www.ebi.ac.uk/pdbsum/5z2w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z2w ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z2w OCA], [https://pdbe.org/5z2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z2w RCSB], [https://www.ebi.ac.uk/pdbsum/5z2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z2w ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/J7Q602_ECOLX J7Q602_ECOLX]] Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.[HAMAP-Rule:MF_00911] [[http://www.uniprot.org/uniprot/A0A1Q6B6Y5_ECOLX A0A1Q6B6Y5_ECOLX]] Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.[HAMAP-Rule:MF_00599][SAAS:SAAS00963806]
+
[https://www.uniprot.org/uniprot/FTSQ_ECOLI FTSQ_ECOLI] Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.[HAMAP-Rule:MF_00911]<ref>PMID:17185541</ref> <ref>PMID:19233928</ref>
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
Bacterial cell division is a fundamental process that results in the physical separation of a mother cell into two daughter cells and involves a set of proteins known as the divisome. Among them, the FtsQ/FtsB/FtsL complex was known as a scaffold protein complex, but its overall structure and exact function is not precisely known. In this study, we have determined the crystal structure of the periplasmic domain of FtsQ in complex with the C-terminal fragment of FtsB, and showed that the C-terminal region of FtsB is a key binding region of FtsQ via mutational analysis in vitro and in vivo. We also obtained the solution structure of the periplasmic FtsQ/FtsB/FtsL complex by small angle X-ray scattering (SAXS), which reveals its structural organization. Interestingly, the SAXS and analytical gel filtration data showed that the FtsQ/FtsB/FtsL complex forms a 2:2:2 heterohexameric assembly in solution with the "Y" shape. Based on the model, the N-terminal directions of FtsQ and the FtsB/FtsL complex should be opposite, suggesting that the Y-shaped FtsQ/FtsB/FtsL complex might fit well into the curved membrane for membrane anchoring.
+
-
Structural Insights into the FtsQ/FtsB/FtsL Complex, a Key Component of the Divisome.,Choi Y, Kim J, Yoon HJ, Jin KS, Ryu S, Lee HH Sci Rep. 2018 Dec 24;8(1):18061. doi: 10.1038/s41598-018-36001-2. PMID:30584256<ref>PMID:30584256</ref>
+
==See Also==
-
 
+
*[[Cell division protein 3D structures|Cell division protein 3D structures]]
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 5z2w" style="background-color:#fffaf0;"></div>
+
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Bacillus coli migula 1895]]
+
[[Category: Escherichia coli]]
-
[[Category: Choi, Y]]
+
[[Category: Large Structures]]
-
[[Category: Lee, H H]]
+
[[Category: Choi Y]]
-
[[Category: Yoon, H J]]
+
[[Category: Lee HH]]
-
[[Category: Cell cycle]]
+
[[Category: Yoon HJ]]
-
[[Category: Cell division]]
+

Current revision

Crystal structure of the bacterial cell division protein FtsQ and FtsB

PDB ID 5z2w

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5z2w"
Personal tools