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5zcj

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Current revision (10:27, 27 March 2024) (edit) (undo)
 
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<StructureSection load='5zcj' size='340' side='right'caption='[[5zcj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='5zcj' size='340' side='right'caption='[[5zcj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zcj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZCJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZCJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zcj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZCJ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zcj OCA], [http://pdbe.org/5zcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zcj RCSB], [http://www.ebi.ac.uk/pdbsum/5zcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zcj ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.004&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zcj OCA], [https://pdbe.org/5zcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zcj RCSB], [https://www.ebi.ac.uk/pdbsum/5zcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zcj ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
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[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TIRR_HUMAN TIRR_HUMAN]] Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299).<ref>PMID:18820299</ref> <ref>PMID:28241136</ref> [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
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[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cui, Y]]
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[[Category: Cui Y]]
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[[Category: Liu, X]]
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[[Category: Liu X]]
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[[Category: Ma, Y]]
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[[Category: Ma Y]]
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[[Category: Wang, J]]
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[[Category: Wang J]]
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[[Category: Wang, M]]
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[[Category: Wang M]]
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[[Category: Xie, R]]
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[[Category: Xie R]]
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[[Category: Yu, X]]
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[[Category: Yu X]]
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[[Category: Yuan, Z]]
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[[Category: Yuan Z]]
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[[Category: Complex]]
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[[Category: Protein binding]]
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Current revision

Crystal structure of complex

PDB ID 5zcj

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