This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5zr6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:28, 27 March 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='5zr6' size='340' side='right'caption='[[5zr6]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='5zr6' size='340' side='right'caption='[[5zr6]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5zr6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZR6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZR6 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5zr6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZR6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZR6 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zr6 OCA], [http://pdbe.org/5zr6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zr6 RCSB], [http://www.ebi.ac.uk/pdbsum/5zr6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zr6 ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zr6 OCA], [https://pdbe.org/5zr6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zr6 RCSB], [https://www.ebi.ac.uk/pdbsum/5zr6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zr6 ProSAT]</span></td></tr>
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/I6Y1Q2_MYCTU I6Y1Q2_MYCTU]
-
The pathogenic Mycobacterium tuberculosis encodes two members of the DtxR family metalloregulators, IdeR and MntR. IdeR represses gene expression in response to ferrous iron, while MntR (Rv2788) functions as a manganese-dependent transcriptional repressor, which represses the expression of manganese transporter genes to maintain manganese homeostasis. Although the structural study towards IdeR is in-depth, there is no MntR structure available. Herein, we report both apo and manganese bound forms of MntR structures from M. tuberculosis. MntR has evolved into two metal ion binding sites like other DtxR proteins and for the first time, we captured the two sites fully occupied by its natural ions with one Mn(2+) ion at the first site and two Mn(2+) ions at the second binding site (binuclear manganese cluster). The conformation change of MntR resulting from manganese binding could prime the MntR for DNA binding, which is a conserved activation mechanism among DtxR family.
+
-
 
+
-
Crystal structures of manganese-dependent transcriptional repressor MntR (Rv2788) from Mycobacterium tuberculosis in apo and manganese bound forms.,Cong X, Yuan Z, Wang Z, Wei B, Xu S, Wang J Biochem Biophys Res Commun. 2018 Jun 22;501(2):423-427. doi:, 10.1016/j.bbrc.2018.05.005. PMID:29730293<ref>PMID:29730293</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 5zr6" style="background-color:#fffaf0;"></div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Cong, X Y]]
+
[[Category: Mycobacterium tuberculosis]]
-
[[Category: Wang, J B]]
+
[[Category: Cong XY]]
-
[[Category: Xu, S J]]
+
[[Category: Wang JB]]
-
[[Category: Transcription]]
+
[[Category: Xu SJ]]
-
[[Category: Transcriptional repressor]]
+

Current revision

Manganese-dependent transcriptional repressor complex with manganese

PDB ID 5zr6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5zr6"
Personal tools