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| | <StructureSection load='5zvw' size='340' side='right'caption='[[5zvw]], [[Resolution|resolution]] 2.29Å' scene=''> | | <StructureSection load='5zvw' size='340' side='right'caption='[[5zvw]], [[Resolution|resolution]] 2.29Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5zvw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bppht Bppht]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZVW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZVW FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5zvw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_phage_phi3T Bacillus phage phi3T] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZVW FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aimR, phi3T_89 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10736 BPPHT])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.292Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zvw OCA], [http://pdbe.org/5zvw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zvw RCSB], [http://www.ebi.ac.uk/pdbsum/5zvw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zvw ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zvw OCA], [https://pdbe.org/5zvw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zvw RCSB], [https://www.ebi.ac.uk/pdbsum/5zvw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zvw ProSAT]</span></td></tr> |
| | </table> | | </table> |
| - | <div style="background-color:#fffaf0;">
| + | == Function == |
| - | == Publication Abstract from PubMed == | + | [https://www.uniprot.org/uniprot/AIMR_BPPHT AIMR_BPPHT] |
| - | Communication is vital for all organisms including microorganisms, which is clearly demonstrated by the bacterial quorum-sensing system. However, the molecular mechanisms underlying communication among viruses (phages) via the quorum-sensing-like 'arbitrium' system remain unclear. Viral or host densities are known to be related to an increased prevalence of lysogeny; however, how the switch from the lytic to the lysogenic pathway occurs is unknown. Thus, we sought to reveal mechanisms of communication among viruses and determine the lysogenic dynamics involved. Structural and functional analyses of the phage-derived SAIRGA and GMPRGA peptides and their corresponding receptors, phAimR and spAimR, indicated that SAIRGA directs the lysis-lysogeny decision of phi3T by modulating conformational changes in phAimR, whereas GMPRGA regulates the lysis-lysogeny pathway by stabilizing spAimR in the dimeric state. Although temperate viruses are thought to share a similar lytic-lysogenic cycle switch model, our study suggests the existence of alternative strain-specific mechanisms that regulate the lysis-lysogeny decision. Collectively, these findings provide insights into the molecular mechanisms underlying communication among viruses, offering theoretical applications for the treatment of infectious viral diseases.
| + | |
| - | | + | |
| - | Structural and functional insights into the regulation of the lysis-lysogeny decision in viral communities.,Dou C, Xiong J, Gu Y, Yin K, Wang J, Hu Y, Zhou D, Fu X, Qi S, Zhu X, Yao S, Xu H, Nie C, Liang Z, Yang S, Wei Y, Cheng W Nat Microbiol. 2018 Nov;3(11):1285-1294. doi: 10.1038/s41564-018-0259-7. Epub, 2018 Oct 15. PMID:30323253<ref>PMID:30323253</ref>
| + | |
| - | | + | |
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
| + | |
| - | </div>
| + | |
| - | <div class="pdbe-citations 5zvw" style="background-color:#fffaf0;"></div>
| + | |
| - | == References ==
| + | |
| - | <references/>
| + | |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Bppht]] | + | [[Category: Bacillus phage phi3T]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Cheng, W]] | + | [[Category: Synthetic construct]] |
| - | [[Category: Dou, C]] | + | [[Category: Cheng W]] |
| - | [[Category: Monomer]] | + | [[Category: Dou C]] |
| - | [[Category: Peptide ligand]]
| + | |
| - | [[Category: Transcription regulator]]
| + | |
