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| | <StructureSection load='5zw6' size='340' side='right'caption='[[5zw6]], [[Resolution|resolution]] 2.05Å' scene=''> | | <StructureSection load='5zw6' size='340' side='right'caption='[[5zw6]], [[Resolution|resolution]] 2.05Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5zw6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpspb Bpspb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZW6 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5zw6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_virus_SPbeta Bacillus virus SPbeta] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZW6 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aimR, yopK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=66797 BPSPB])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zw6 OCA], [http://pdbe.org/5zw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zw6 RCSB], [http://www.ebi.ac.uk/pdbsum/5zw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zw6 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zw6 OCA], [https://pdbe.org/5zw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zw6 RCSB], [https://www.ebi.ac.uk/pdbsum/5zw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zw6 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/AIMR_BPSPB AIMR_BPSPB]] Transcriptional regulator which is part of the latency-replication switch system that decides at the onset of infection whether to replicate and lyse the host or to lysogenize (latency) and keep the host viable. Activates the transcription of the aimX locus. Transcriptional activation of aimX seems to lead to the productive viral replication (lytic cycle), aimX possibly acting as a regulatory non-coding RNA.[UniProtKB:P0DOE3] | + | [https://www.uniprot.org/uniprot/AIMR_BPSPB AIMR_BPSPB] Transcriptional regulator which is part of the latency-replication switch system that decides at the onset of infection whether to replicate and lyse the host or to lysogenize (latency) and keep the host viable. Activates the transcription of the aimX locus. Transcriptional activation of aimX seems to lead to the productive viral replication (lytic cycle), aimX possibly acting as a regulatory non-coding RNA.[UniProtKB:P0DOE3] |
| - | <div style="background-color:#fffaf0;">
| + | |
| - | == Publication Abstract from PubMed ==
| + | |
| - | Communication is vital for all organisms including microorganisms, which is clearly demonstrated by the bacterial quorum-sensing system. However, the molecular mechanisms underlying communication among viruses (phages) via the quorum-sensing-like 'arbitrium' system remain unclear. Viral or host densities are known to be related to an increased prevalence of lysogeny; however, how the switch from the lytic to the lysogenic pathway occurs is unknown. Thus, we sought to reveal mechanisms of communication among viruses and determine the lysogenic dynamics involved. Structural and functional analyses of the phage-derived SAIRGA and GMPRGA peptides and their corresponding receptors, phAimR and spAimR, indicated that SAIRGA directs the lysis-lysogeny decision of phi3T by modulating conformational changes in phAimR, whereas GMPRGA regulates the lysis-lysogeny pathway by stabilizing spAimR in the dimeric state. Although temperate viruses are thought to share a similar lytic-lysogenic cycle switch model, our study suggests the existence of alternative strain-specific mechanisms that regulate the lysis-lysogeny decision. Collectively, these findings provide insights into the molecular mechanisms underlying communication among viruses, offering theoretical applications for the treatment of infectious viral diseases.
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| - | Structural and functional insights into the regulation of the lysis-lysogeny decision in viral communities.,Dou C, Xiong J, Gu Y, Yin K, Wang J, Hu Y, Zhou D, Fu X, Qi S, Zhu X, Yao S, Xu H, Nie C, Liang Z, Yang S, Wei Y, Cheng W Nat Microbiol. 2018 Nov;3(11):1285-1294. doi: 10.1038/s41564-018-0259-7. Epub, 2018 Oct 15. PMID:30323253<ref>PMID:30323253</ref>
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| - | | + | |
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| - | </div>
| + | |
| - | <div class="pdbe-citations 5zw6" style="background-color:#fffaf0;"></div>
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| - | == References ==
| + | |
| - | <references/>
| + | |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Bpspb]] | + | [[Category: Bacillus virus SPbeta]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Cheng, W]] | + | [[Category: Synthetic construct]] |
| - | [[Category: Dou, C]] | + | [[Category: Cheng W]] |
| - | [[Category: Dimer]] | + | [[Category: Dou C]] |
| - | [[Category: Phage spbeta]]
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| - | [[Category: Transcription regulator]]
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