6a85

<StructureSection load='6a85' size='340' side='right' caption='[[6a85]], [[Resolution|resolution]] 1.45&Aring;' scene=''>

<table><tr><td colspan='2'>[[6a85]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A85 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A85 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a85 OCA], [http://pdbe.org/6a85 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a85 RCSB], [http://www.ebi.ac.uk/pdbsum/6a85 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a85 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

DNA can form diverse structures, which predefine their physiological functions. Besides duplexes that carry the genetic information, quadruplexes are the most well-studied DNA structures. In addition to their important roles in recombination, replication, transcription and translation, DNA quadruplexes have also been applied as diagnostic aptamers and antidisease therapeutics. Herein we further expand the sequence and structure complexity of DNA quadruplex by presenting a high-resolution crystal structure of DNA1 (5'-AGAGAGATGGGTGCGTT-3'). This is the first quadruplex structure that contains all the internal A-, G-, C-, T-tetrads, A:T:A:T tetrads and bulged nucleotides in one single structure; as revealed by site-specific mutagenesis and biophysical studies, the central ATGGG motif plays important role in the quadruplex formation. Interestingly, our structure also provides great new insights into cation recognition, including the first-time reported Pb2+, by tetrad structures.

High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads.,Liu H, Wang R, Yu X, Shen F, Lan W, Haruehanroengra P, Yao Q, Zhang J, Chen Y, Li S, Wu B, Zheng L, Ma J, Lin J, Cao C, Li J, Sheng J, Gan J Nucleic Acids Res. 2018 Nov 30;46(21):11627-11638. doi: 10.1093/nar/gky902. PMID:30285239<ref>PMID:30285239</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 6a85" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Gan, J H]]

[[Category: Liu, H H]]

[[Category: Dna]]

[[Category: Quadruplex]]