1rca

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1rca.jpg|left|200px]]
[[Image:1rca.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1rca |SIZE=350|CAPTION= <scene name='initialview01'>1rca</scene>, resolution 1.9&Aring;
+
The line below this paragraph, containing "STRUCTURE_1rca", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CGP:2&#39;-DEOXYCYTIDINE-2&#39;-DEOXYGUANOSINE-3&#39;,5&#39;-MONOPHOSPHATE'>CGP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1rca| PDB=1rca | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rca OCA], [http://www.ebi.ac.uk/pdbsum/1rca PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rca RCSB]</span>
+
-
}}
+
'''STRUCTURE OF THE CRYSTALLINE COMPLEX OF DEOXYCYTIDYLYL-3',5'-GUANOSINE (3',5'-DCPDG) CO-CRYSTALISED WITH RIBONUCLEASE AT 1.9 ANGSTROMS RESOLUTION. RETROBINDING IN PANCREATIC RNASEA IS INDEPENDENT OF MODE OF INHIBITOR INTROMISSION'''
'''STRUCTURE OF THE CRYSTALLINE COMPLEX OF DEOXYCYTIDYLYL-3',5'-GUANOSINE (3',5'-DCPDG) CO-CRYSTALISED WITH RIBONUCLEASE AT 1.9 ANGSTROMS RESOLUTION. RETROBINDING IN PANCREATIC RNASEA IS INDEPENDENT OF MODE OF INHIBITOR INTROMISSION'''
Line 28: Line 25:
[[Category: Lisgarten, J N.]]
[[Category: Lisgarten, J N.]]
[[Category: Palmer, R A.]]
[[Category: Palmer, R A.]]
-
[[Category: hydrolase (endoribonuclease)]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:19:36 2008''
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:26:06 2008''
+

Revision as of 04:19, 3 May 2008

Image:1rca.jpg

Template:STRUCTURE 1rca

STRUCTURE OF THE CRYSTALLINE COMPLEX OF DEOXYCYTIDYLYL-3',5'-GUANOSINE (3',5'-DCPDG) CO-CRYSTALISED WITH RIBONUCLEASE AT 1.9 ANGSTROMS RESOLUTION. RETROBINDING IN PANCREATIC RNASEA IS INDEPENDENT OF MODE OF INHIBITOR INTROMISSION


Overview

The X-ray structure of bovine ribonuclease A cocrystallized with the dinucleotide deoxycytidylyl-3',5'-guanosine has been determined at 1.9 A resolution and refined by restrained least squares to R = 0.218 for 7807 reflections. The structure established that the recently observed retrobound mode of attachment of substrate analogues cytidylyl-2',5'-guanosine and deoxycytidylyl-3',5'-guanosine found in soaked RNase A crystals is also present in the cocrystallized complex. Retrobinding is thus unlikely to be the result of restrictions imposed by the crystalline environment as the ligands soak into the lattice but rather a phenomenon specific to small nucleotides containing guanine.

About this Structure

1RCA is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure of the crystalline complex of deoxycytidylyl-3',5'-guanosine (3',5'-dCpdG) cocrystallized with ribonuclease at 1.9 A resolution., Listgarten JN, Maes D, Wyns L, Aguilar CF, Palmer RA, Acta Crystallogr D Biol Crystallogr. 1995 Sep 1;51(Pt 5):767-71. PMID:15299807 Page seeded by OCA on Sat May 3 07:19:36 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rca"
Personal tools