6ign
From Proteopedia
(Difference between revisions)
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<StructureSection load='6ign' size='340' side='right'caption='[[6ign]], [[Resolution|resolution]] 3.45Å' scene=''> | <StructureSection load='6ign' size='340' side='right'caption='[[6ign]], [[Resolution|resolution]] 3.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6ign]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IGN OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6ign]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IGN FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.451Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ign FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ign OCA], [https://pdbe.org/6ign PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ign RCSB], [https://www.ebi.ac.uk/pdbsum/6ign PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ign ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/KINH_MOUSE KINH_MOUSE] Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. May be involved in the mechanisms of growth arrest induced by exposure to DNA-damaging drugs or by cellular senescence (PubMed:9657148). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (PubMed:21976701). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).[UniProtKB:P33176][UniProtKB:Q2PQA9]<ref>PMID:21976701</ref> <ref>PMID:9657148</ref> |
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| + | ==See Also== | ||
| + | *[[Kinesin 3D Structures|Kinesin 3D Structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: | + | [[Category: Kong B]] |
| - | [[Category: | + | [[Category: Sun WP]] |
| - | [[Category: | + | [[Category: Zhang SJ]] |
| - | + | ||
Current revision
The crystal structure of Kif5b stalk 1 coiled-coil region
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