6jbj

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Current revision (10:37, 27 March 2024) (edit) (undo)
 
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<SX load='6jbj' size='340' side='right' viewer='molstar' caption='[[6jbj]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
<SX load='6jbj' size='340' side='right' viewer='molstar' caption='[[6jbj]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6jbj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JBJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JBJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6jbj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JBJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JBJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABCD4, PXMP1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jbj OCA], [http://pdbe.org/6jbj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jbj RCSB], [http://www.ebi.ac.uk/pdbsum/6jbj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jbj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jbj OCA], [https://pdbe.org/6jbj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jbj RCSB], [https://www.ebi.ac.uk/pdbsum/6jbj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jbj ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/ABCD4_HUMAN ABCD4_HUMAN]] Methylmalonic acidemia with homocystinuria, type cblJ. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/ABCD4_HUMAN ABCD4_HUMAN] Methylmalonic acidemia with homocystinuria, type cblJ. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ABCD4_HUMAN ABCD4_HUMAN]] May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm.<ref>PMID:22922874</ref>
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[https://www.uniprot.org/uniprot/ABCD4_HUMAN ABCD4_HUMAN] May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm.<ref>PMID:22922874</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</SX>
</SX>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, Y]]
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[[Category: Chen Y]]
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[[Category: Feng, Z]]
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[[Category: Feng Z]]
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[[Category: Hou, W T]]
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[[Category: Hou WT]]
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[[Category: Jiang, Y L]]
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[[Category: Jiang YL]]
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[[Category: Sun, L F]]
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[[Category: Sun LF]]
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[[Category: Wang, L]]
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[[Category: Wang L]]
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[[Category: Xu, D]]
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[[Category: Xu D]]
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[[Category: Zhou, C Z]]
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[[Category: Zhou CZ]]
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[[Category: Atp-bound]]
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[[Category: Human abcd4]]
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[[Category: Lysosomal cobalamin exporter]]
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[[Category: Lysosome-open conformation]]
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[[Category: Membrane protein]]
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Current revision

Cryo-EM structure of human lysosomal cobalamin exporter ABCD4

6jbj, resolution 3.60Å

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OCA

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