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| | <StructureSection load='6jbx' size='340' side='right'caption='[[6jbx]], [[Resolution|resolution]] 2.20Å' scene=''> | | <StructureSection load='6jbx' size='340' side='right'caption='[[6jbx]], [[Resolution|resolution]] 2.20Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6jbx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JBX FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6jbx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JBX FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRD:TRIDECANE'>TRD</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">marR_1, fabT, marR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRD:TRIDECANE'>TRD</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jbx OCA], [http://pdbe.org/6jbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jbx RCSB], [http://www.ebi.ac.uk/pdbsum/6jbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jbx ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jbx OCA], [https://pdbe.org/6jbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jbx RCSB], [https://www.ebi.ac.uk/pdbsum/6jbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jbx ProSAT]</span></td></tr> |
| | </table> | | </table> |
| - | <div style="background-color:#fffaf0;">
| + | == Function == |
| - | == Publication Abstract from PubMed == | + | [https://www.uniprot.org/uniprot/Q8DR18_STRR6 Q8DR18_STRR6] |
| - | The Streptococcus pneumoniae fatty acid synthesis pathway is globally controlled at the transcriptional level by the repressor FabT and its co-repressor acyl carrier protein (acyl-ACP), the intermediate of phospholipid synthesis. Here, we report the crystal structure of FabT complexed with a 23-bp dsDNA, which indicates that FabT is a weak repressor with low DNA-binding affinity in the absence of acyl-ACP. Modification of ACP with a long-chain fatty acid is necessary for the formation of a stable complex with FabT, mimicked in vitro by cross-linking, which significantly elevates the DNA-binding affinity of FabT. Altogether, we propose a putative working model of gene repression under the double control of FabT and acyl-ACP, elucidating a distinct repression network for Pneumococcus to precisely coordinate fatty acid synthesis. This article is protected by copyright. All rights reserved.
| + | |
| - | | + | |
| - | Structural insights into repression of the Pneumococcal fatty acid synthesis pathway by repressor FabT and co-repressor acyl-ACP.,Zuo G, Chen ZP, Jiang YL, Zhu Z, Ding C, Zhang Z, Chen Y, Zhou CZ, Li Q FEBS Lett. 2019 Jul 10. doi: 10.1002/1873-3468.13534. PMID:31291684<ref>PMID:31291684</ref>
| + | |
| - | | + | |
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
| + | |
| - | </div>
| + | |
| - | <div class="pdbe-citations 6jbx" style="background-color:#fffaf0;"></div>
| + | |
| - | == References ==
| + | |
| - | <references/>
| + | |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Chen, Z P]] | + | [[Category: Streptococcus pneumoniae]] |
| - | [[Category: Li, Q]] | + | [[Category: Chen ZP]] |
| - | [[Category: Zhou, C Z]] | + | [[Category: Li Q]] |
| - | [[Category: Zuo, G]] | + | [[Category: Zhou CZ]] |
| - | [[Category: Fatty acid synthesis]] | + | [[Category: Zuo G]] |
| - | [[Category: Marr family]]
| + | |
| - | [[Category: Transcription factor]]
| + | |
| - | [[Category: Transcription-dna complex]]
| + | |
