We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

6jcs

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<SX load='6jcs' size='340' side='right' viewer='molstar' caption='[[6jcs]], [[Resolution|resolution]] 3.18&Aring;' scene=''>
<SX load='6jcs' size='340' side='right' viewer='molstar' caption='[[6jcs]], [[Resolution|resolution]] 3.18&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6jcs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Adeno-associated_virus_-_5 Adeno-associated virus - 5] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JCS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JCS FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6jcs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Adeno-associated_virus_5 Adeno-associated virus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JCS FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIAA0319L, AAVR, KIAA1837, PP791 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.18&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jcs OCA], [http://pdbe.org/6jcs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jcs RCSB], [http://www.ebi.ac.uk/pdbsum/6jcs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jcs ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jcs OCA], [https://pdbe.org/6jcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jcs RCSB], [https://www.ebi.ac.uk/pdbsum/6jcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jcs ProSAT]</span></td></tr>
</table>
</table>
-
== Disease ==
 
-
[[http://www.uniprot.org/uniprot/K319L_HUMAN K319L_HUMAN]] Systemic lupus erythematosus;Limited cutaneous systemic sclerosis.
 
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/K319L_HUMAN K319L_HUMAN]] Possible role in axon guidance through interaction with RTN4R.<ref>PMID:20697954</ref>
+
[https://www.uniprot.org/uniprot/Q9YIJ1_9VIRU Q9YIJ1_9VIRU]
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
Adeno-associated virus (AAV) receptor (AAVR) is an essential receptor for the entry of multiple AAV serotypes with divergent rules; however, the mechanism remains unclear. Here, we determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, revealing the molecular details by which PKD1 recognizes AAV5 and PKD2 is solely engaged with AAV1. PKD2 lies on the plateau region of the AAV1 capsid. However, the AAV5-AAVR interface is strikingly different, in which PKD1 is bound at the opposite side of the spike of the AAV5 capsid than the PKD2-interacting region of AAV1. Residues in strands F/G and the CD loop of PKD1 interact directly with AAV5, whereas residues in strands B/C/E and the BC loop of PKD2 make contact with AAV1. These findings further the understanding of the distinct mechanisms by which AAVR recognizes various AAV serotypes and provide an example of a single receptor engaging multiple viral serotypes with divergent rules.
+
-
Divergent engagements between adeno-associated viruses with their cellular receptor AAVR.,Zhang R, Xu G, Cao L, Sun Z, He Y, Cui M, Sun Y, Li S, Li H, Qin L, Hu M, Yuan Z, Rao Z, Ding W, Rao Z, Lou Z Nat Commun. 2019 Aug 21;10(1):3760. doi: 10.1038/s41467-019-11668-x. PMID:31434885<ref>PMID:31434885</ref>
+
==See Also==
-
 
+
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 6jcs" style="background-color:#fffaf0;"></div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</SX>
</SX>
-
[[Category: Adeno-associated virus - 5]]
+
[[Category: Adeno-associated virus 5]]
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Lou, Z]]
+
[[Category: Lou Z]]
-
[[Category: Zhang, R]]
+
[[Category: Zhang R]]
-
[[Category: Aav5]]
+
-
[[Category: Aavr]]
+
-
[[Category: Adeno-associated virus]]
+
-
[[Category: Receptor]]
+
-
[[Category: Virus]]
+

Revision as of 10:37, 27 March 2024

AAV5 in complex with AAVR

6jcs, resolution 3.18Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6jcs"
Personal tools