6k3i

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<SX load='6k3i' size='340' side='right' viewer='molstar' caption='[[6k3i]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
<SX load='6k3i' size='340' side='right' viewer='molstar' caption='[[6k3i]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6k3i]] is a 66 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K3I OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6K3I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6k3i]] is a 66 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K3I FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6k3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k3i OCA], [http://pdbe.org/6k3i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k3i RCSB], [http://www.ebi.ac.uk/pdbsum/6k3i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k3i ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.86&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k3i OCA], [https://pdbe.org/6k3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k3i RCSB], [https://www.ebi.ac.uk/pdbsum/6k3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k3i ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/FLGE_SALTY FLGE_SALTY]
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Bacterial locomotion by rotating flagella is achieved through the hook, which transmits torque from the motor to the filament. The hook is a tubular structure composed of a single type of protein, yet it adopts a curved shape. To perform its function, it must be simultaneously flexible and torsionally rigid. The molecular mechanism by which chemically identical subunits form such a dynamic structure is unknown. Here, we show the complete structure of the hook from Salmonella enterica in its supercoiled 'curved' state, at 2.9 A resolution. Subunits in the curved hook are grouped into 11 distinctive conformations, each shared along 11 protofilaments. The domains of the elongated hook subunit behave as rigid bodies connected by two hinge regions. The reconstituted model demonstrates how identical subunits can dynamically change conformation by physical interactions while bending. These multiple subunit states contradict the two-state model, which is a key feature of flagellar polymorphism.
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Torque transmission mechanism of the curved bacterial flagellar hook revealed by cryo-EM.,Shibata S, Matsunami H, Aizawa SI, Wolf M Nat Struct Mol Biol. 2019 Sep 30. pii: 10.1038/s41594-019-0301-3. doi:, 10.1038/s41594-019-0301-3. PMID:31570877<ref>PMID:31570877</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6k3i" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Salty]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Aizawa, S]]
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[[Category: Aizawa S]]
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[[Category: Matsunami, H]]
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[[Category: Matsunami H]]
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[[Category: Shibata, S]]
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[[Category: Shibata S]]
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[[Category: Wolf, M]]
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[[Category: Wolf M]]
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[[Category: Bacterial]]
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[[Category: Flagella]]
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[[Category: Flexible joint]]
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[[Category: Hook]]
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[[Category: Motor protein]]
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Current revision

Salmonella hook in curved state - 66 subunit models

6k3i, resolution 2.86Å

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