6klp

<table><tr><td colspan='2'>[[6klp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KLP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KLP FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6klp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6klp OCA], [http://pdbe.org/6klp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6klp RCSB], [http://www.ebi.ac.uk/pdbsum/6klp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6klp ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Troponin is an essential component of striated muscle and it regulates the sliding of actomyosin system in a calcium-dependent manner. Despite its importance, the structure of troponin has been elusive due to its high structural heterogeneity. In this study, we analyzed the 3D structures of murine cardiac thin filaments using a cryo-electron microscope equipped with a Volta phase plate (VPP). Contrast enhancement by a VPP enabled us to reconstruct the entire repeat of the thin filament. We determined the orientation of troponin relative to F-actin and tropomyosin, and characterized the interactions between troponin and tropomyosin. This study provides a structural basis for understanding the molecular mechanism of actomyosin system.

Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin.,Oda T, Yanagisawa H, Wakabayashi T J Struct Biol. 2020 Jan 16:107450. doi: 10.1016/j.jsb.2020.107450. PMID:31954841<ref>PMID:31954841</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 6klp" style="background-color:#fffaf0;"></div>

*[[Tropomyosin|Tropomyosin]]

[[Category: Oda, T]]

[[Category: Wakabayashi, T]]

[[Category: Yanagisawa, H]]

[[Category: Contractile protein]]